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differential hematology systemic algorithm causes generalized leukemia cll cryofibrinogenemia cryoglobulinemia cryoglobulins cutaneous dermatologic erythematosus granulomatosis joint lupus lymphocytic mds monoclonal
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... associated with pruritus ... Differential Diagnosis ... • Goodpasture syndrome ... #diagnosis #rheumatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Creatinine & BUN: • Chronic ... Differential: • Lymphoma ... syndrome Psychiatric ... #primary #secondary ... #generalized #dermatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Secondary: CTD ... : • Behcet Disease ... • Cogan syndrome ... #skin #dermatology ... #rheumatology #
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Skin Lesion - Differential ... Creatinine & BUN: • Chronic ... Differential: • Lymphoma ... syndrome Psychiatric ... #secondary #systemic
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... leakage of RBC's secondary ... #hematology #rheumatology ... #nonpalpable #dermatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Dermatomyositis Erythema chronicum ... Sarcoidosis • GPA ... Sarcoidosis #dermatology ... #differential #diagnosis ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... Eosinophilia, asthma, chronic ... • ANCA (Dx: GPA ... #rheumatology # ... classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... Type III Often Secondary ... - GPA, EGPA, microscopic ... #types #classification ... #rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... Alpha & Mu) Skin ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... DDX: Rule Out Secondary ... Marrow Failure • Chronic ... #Syndromes #diagnosis ... #hematology #oncology
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