12 results
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Creatinine & BUN: • Chronic ... Differential: • Lymphoma ... syndrome Psychiatric ... #primary #secondary ... #generalized #dermatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
Skin Lesion - Differential ... Creatinine & BUN: • Chronic ... Differential: • Lymphoma ... syndrome Psychiatric ... #secondary #systemic
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
associated with pruritus ... Differential Diagnosis ... • Goodpasture syndrome ... #rash #diagnosis ... #rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Marginal Zone Lymphoma ... • Heavy Chain disease ... Alpha & Mu) Skin ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... • Autoimmune diseases ... Type III Often Secondary ... #types #classification ... #rheumatology #
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... AIHA Primary Secondary ... Cold Agglutinin Syndrome ... - Lymphoid Malignancy ... hemolytic #anemia #hematology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... Ischemia, Leukemia, Lymphoma ... Recurrent and chronic ... : monoclonal TNF-aIpha ... signs #symptoms #rheumatology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... DDX: Rule Out Secondary ... Marrow Failure • Chronic ... #Syndromes #diagnosis ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Hepatomegaly • Skin ... cells can indicate disease ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... bone marrow and secondary ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis