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hematology differential leukemia cvid dermatologic gpa granulomatosis hypogammaglobulinemia immunodeficiency immunology lymphocytic management mds monoclonal myelodysplasia paraproteinemias polyangiitis protein proteingap rash
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
) is common and ... or more commonly ... GPA causes disease ... • Goodpasture syndrome ... #diagnosis #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Hepatomegaly • Skin ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... -> Invade Skin: ... #Hematology #Oncology ... #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Most common cytopenia ... Causes • Anemia ... #Syndromes #diagnosis ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
globulin gap (> ... gastric tumors • Hematology ... anemia • Other ... Comment on type ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
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