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differential management agglutinin allergy behcet common cvid hypogammaglobulinemia immunodeficiency lupus monoclonal paraproteinemias pathergy signs symptoms tafro thrombocytopenia variable workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... SLL CLL Epidemiology ... #Chronic #Lymphocytic ... #Leukemia #diagnosis ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... (Chronic Lymphocytic ... lymphoma (SLL) ... Lymphocytic Lymphoma ... #Hematology #Oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Diagnosis: • hemolytic ... anemia • Cold ... #hemolytic #anemia ... #hematology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic ... and leukemia • ... #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Granulomatous lymphocytic ... and autoimmune hemolytic ... anemia) • Systemic ... hypogammaglobulinemia #immunology ... #hematology #diagnosis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... tears, Ischemia, Leukemia ... , Lymphoma Ocular ... Recurrent and chronic ... signs #symptoms #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
as SLE, atherosclerotic ... : Erythematous nodules ... elevated protein, lymphocytic ... Eosinophilia, asthma, chronic ... #Rheumatology
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
Skin trauma → Erythematous ... • Chronic myeloid ... leukemia (CML) ... Non-Hodgkin's lymphoma ... #dermatology #skin
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
lupus erythematosus ... (SLE), Sjögren’ ... lymphoma - Intravascular ... large B cell lymphoma ... #management #rheumatology
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