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diagnosis management erythematosus hemophagocytic hlh lupus lymphohistiocytosis sle systemic treatment activation bandemia cbc cerebritis classification cns comparison crisis differential eularacr
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH) Clinical ... ↑ AST & ALT, ↑ LDH ... the following 8 criteria ... Lymphohistiocytosis #diagnosis #hematology ... #criteria
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... Erythematosus Clinical ... Delirium, Psychosis, Seizure ... Classification #Criteria ... Erythematosus #diagnosis #rheumatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... blood donor • Pathophysiology ... : ARDS Berlin Criteria ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Movement disorders, Seizure ... Disease, PRES Pathophysiology ... CNS #neurology #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Assessment • Clinical ... >2400 Ul/ml, ↑ LDH ... treatment #summary #rheumatology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Diagnosis: • Seizures ... likelihood of negative clinical ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Fever is the main clinical ... 10,000 ng/mL • Hyponatremia ... Histopathologic criteria ... Diagnosis #Management #Hematology ... #Rheumatology
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Crisis (SRC) Clinical ... anemia (MAHA) Pathophysiology ... uncontrolled with ACEi, add ... Renal #Crisis #rheumatology
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