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hematology febrile hemophagocytic hlh infant lp risk stepbystep stratification anemia aplastic ebm macrophage mas oncology summary
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... following: • Fever ... #diagnosis #management ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... →Activation of CD8 ... • Clinical: fever ... #diagnosis #management ... #rheumatology
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... serious bacterial infections ... #Management #Pediatrics ... #Peds #Febrile ... #LP #Antibiotics
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
treatment. http ... 92.0% and 46.9% #Diagnosis ... #EBM #Management ... #Pediatrics #Peds ... Stratification #Fever
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia - Overview ... Presentation: • Fever ... - β-lactam antibiotics ... aplastic anemia Treatment ... #diagnosis #management
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