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diagnosis hematology anemia aplastic cppd deposition disease febrile hemophagocytic hlh infant leukostasis lp lymphohistiocytosis lysis macrophage oncology pseudogout pyrophosphate risk
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... serious bacterial infections ... #Diagnosis #Management ... #Pediatrics #Peds ... #LP #Antibiotics
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: - Neuro: AMS ... - 80% have fever ... ischemia, bowel infarction ... TLS #diagnosis #management ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia - Overview ... Presentation: • Fever ... - β-lactam antibiotics ... aplastic anemia Treatment ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... following: • Fever ... rapidly, and empiric antibiotic ... #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Syndrome (MAS) ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... #Management #Hematology ... #Rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
diagnose concomitant infection ... Acute Pseudogout: Treatment ... Crowned Dens Syndrome ... acute neck pain, fever ... #diagnosis #management
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