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diagnosis hematology differential management blood reactions algorithm anemia biliary cholangitis classification common cvid disorders extravascular gap globulin hemolytic hepatitis hodgkins
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... e.g. lupus, CLL, lymphoma ... • Intrinsic RBC ... Extravascular #Causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... cell lung CA, lymphoma ... hepatitis: < 1 • Cirrhosis ... (hemolysis) • ... diagnosis #algorithm #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... Diagnosis and Workup ... : INR/PT, aPTT(liver ... bypass), LFT (liver ... #Workup #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... /Liver failure ... Endocrinopathy, Lymphoma ... #diagnosis #workup ... #hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... Fibrin degradation products ... from ischemia WBC ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... severe thrombocytopenia ... TRALI): Leading cause ... eruptions, diarrhea, liver ... more likely to cause
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... genes and gene products ... Workup: • Full ... platelets - WBC ... classification #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... severe thrombocytopenia ... TRALI): Leading cause ... eruptions, diarrhea, liver ... diagnosis #management #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... • Nodules • Lymphoid ... specifically immune thrombocytopenia ... and autoimmune hemolytic ... DDX - Other causes
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Amyloidosis • Lymphoma ... Sarcoidosis) • Liver ... disease: Cirrhosis ... autoimmune hepatitis, PBC
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