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diagnosis hematology disease glomerular management nephrology agglutinin biliary cell cholangitis chronic cirrhosis classification cll cold cvid differential gap globulin glomerulonephritis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Monoclonal - Lymphoid ... symptoms - most common ... Positive Coombs testing ... Blood smear - RBC ... #anemia #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... anemia • Pain ... (NSHL) - (most common ... Workup: • Full ... #oncology #management
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Female:Male 9:1 • Common ... intralobular bile ducts causes ... Endocrinopathy, Lymphoma ... cholangitis #diagnosis #workup ... #hepatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... Lymphocytosis on CBC ... • Neutropenia, anemia ... Leukemia #diagnosis #workup ... #oncology #hematology
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Spot PC (protein ... LDH - Assess for hemolysis ... infections are common ... causes of glomerular ... #workup #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Nodules • Lymphoid ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia: • Nephrotic
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Spot PC (protein ... LDH - Assess for hemolysis ... infections are common ... causes of glomerular ... glomerular #disease #workup
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... Most common cytopenia ... Workup: • Complete ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Amyloidosis • Lymphoma ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia ... Comment on type
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• No CRAB - no anemia ... • Non-Hodgkin Lymphoma ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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