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differential management symptoms causes algorithm aptt coagulation erythematosus lupus prolonged sle pt treatment workup acute adultonset anorexianervosa arteritis autoantibodies bleeding
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
to Evaluate an Abnormal ... K Antagonists, Heparin ... ) Step 3: Is a Systemic ... APTT #prolonged #diagnosis ... #hematology #evaluation
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... Leucopenia/lymphopenia, Thrombocytopenia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... skin thickening Signs ... pericarditis • Hepatic ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
- Differential Diagnosis ... Algorithm Thrombocytopenia ... Destruction • Abnormal ... Disease Vascular System ... Algorithm #Causes #Hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... TMA: Unexplained thrombocytopenia ... hemoglobin/hemosiderin, Hepatic ... hemosiderin • PT/aPTT normal ... Management #Algorithm #hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
guidelines General - Systemic ... splenomegaly, abnormal ... cell disease Rheumatology ... #Child #Peds #Pediatrics ... #Diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... #Coagulation #diagnosis ... treatment #management #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Neurological 12% - Thrombocytopenia ... Lupusreference #SLE #Systemic ... autoantibodies #signs ... #differential #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... solid cancers • Systemic ... splenomegaly • Hepatic ... Stills #Disease #diagnosis ... management #treatment #rheumatology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... thrombin inhibitors, heparin ... associated with systemic ... amyloidosis #Abnormal ... #differential #hematology
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