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Medications associated with drug-induced lupus

List of Definite and Possible Associated Drugs

#Diagnosis #Pharmacology #Medications #DrugInduced #Lupus #List
associated with drug-induced ... Possible Associated Drugs ... #Diagnosis #Pharmacology ... #List #Causes #Differential ... #Drugs
Lupus Classification
Spontaneous Lupus
 - Cutaneous Lupus Erythematosus (CLE)
 - Systemic Lupus Erythematosus 
Drug-Induced Lupus
 - Drug-Induced
Drug-Induced ... Lupus - Drug-Induced ... (SCLE-DIL) - Drug-Induced ... #rheumatology #diagnosis ... #differential
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
lupus erythematosus ... disease (MCTD), Drug-induced ... Lupus, Juvenile ... #rheumatology #diagnosis ... #differential
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... cases, drug-dependent ... - Less common (drug-dependent ... Discontinuation of causal drug
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Drug Induced Systemic ... > 100 drugs have ... associated with drug-induced ... #medications #drugs ... #pharmacology #
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
disease (MCTD), Drug-induced ... Idiopathic Arthritis, Drug-Induced ... Biliary Cirrhosis, Drug-Induced ... #rheumatology #diagnosis ... #differential
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Diagnosis Algorithm ... syndromes • Drugs ... • Emboli Systemic ... (E. coli) • Drugs ... Nephritis • Drugs
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Secondary GNs: Due to systemic ... disease or drugs ... Post-infectious GN, Lupus ... hypotension • Drugs ... Nephritis (AIN) • Drugs
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... (aPL) 30-45% Differential ... Diagnosis and Lupus ... Mimickers: Drug-induced ... Lupusreference #SLE #Systemic
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
abscess • Toxic/drug ... nodosa) • Toxic/drug ... Hypoglycemia • Drugs ... dystrophies Work ... myositis, certain drug-induced