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rheumatology differential management granulomatosis polyangiitis aav associated classification eosinophilic glomerulonephritis gpa laboratory microscopic mpa panca positivity progressive pulmonary rapidly renal
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA ... polyangiitis (EGPA ... antibody) - P-ANCA ... #CANCA #PANCA # ... MPO #PR3 #Diagnosis
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
p-ANCA GPA → usually ... c-ANCA EGPA → ... P-ANCA (MPO) ... C-ANCA (PR3) X-ANCA ... ANCA Vasculitis
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
GPA - PR3-ANCA 75% ... • MPA - PR3-ANCA ... • EGPA - PR3- ... - PR3-ANCA 10%, ... #PR3 #diagnosis
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (GPA ... ) - ANCA Vasculitis ... #ANCA #Vasculitis ... #Management #Treatment ... #ACR2021 #Guidelines
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Negative IF): • PR3 ... -ANCA (C-ANCA): ... GPA >>> MPA > eGPA ... • MPO-ANCA (P-ANCA ... ): eGPA, MPA >>>
Vasculitis Management - ACR/VF 2021 Guidelines for Treatment & Management • Giant Cell Arteritis (GCA) •
for Treatment & ... Polyangiitis (GPA ... Polyangiitis (MPA ... #ACR2021 #Guidelines ... #algorithm #rheumatology
Eosinophilic Granulomatosis with Polyangiitis (EGPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021 Guidelines • Active
) - ANCA Vasculitis ... alone in select pts ... #Polyangiitis #ANCA ... #Treatment #ACR2021 ... #Guidelines #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
myeloperoxidase (MPO-ANCA ... > PR3 60% • GPA ... 100 % Commonly MPO-ANCA ... Vasculitis: + MPO-ANCA ... (Dx: GPA, EGPA,
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... Renal Syndromes (PRS ... defining feature, PRS ... Auto-antibodies: ANCA ... of PRS: Biopsy
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
myeloperoxidase (MPO-ANCA ... proteinase 3 (PR3 ... > PR3) • Pulmonary ... > PR3 60/ GPA ... 90 percent have PR3
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