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diagnosis hematology differential causes hemolytic leukemia management algorithm biliary chronic cirrhosis lymphocytic monoclonal agglutinin apml cell cholangitis classification cold differentiation
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... Pathophysiology ... Labs: • Alkaline ... cholangitis #diagnosis #workup ... #hepatology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... relative with PBC ... Cholestasis #PBC ... #Primary #Biliary ... #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... changes), high MCV anemia ... not required in all ... unclear, or if a primary ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• ↑ PBS: Granulocytic ... - infiltrates (anemia ... + distinctive primary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... lymphoproliferative disorders ... • Neutropenia, anemia ... Leukemia #diagnosis #workup ... #oncology #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... (BM) ablative disorders ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... usually IgM) (e.g. primary ... lymphoproliferative disorders ... • Intrinsic RBC ... #anemia
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... a decrease in all ... Leukopenia is primarily ... involves production disorders ... that involves disorders
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... membrane disorder ... Diagnosis #Algorithm #workup ... #hematology #testing
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... • Symptoms of anemia ... • hemolytic anemia ... Blood smear - RBC ... #hematology #diagnosis
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