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diagnosis hematology aplastic cell common cvid differential disorders gap globulin hodgkins hypogammaglobulinemia immunodeficiency immunology leukemia lymphoproliferative plasmacytoma post protein proteingap
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... ) Classification ... #hematology #oncology ... #management
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
PTLD) Definition: Lymphoid ... in lung>heart>liver ... Diagnosis and classification ... Lymphoproliferative #Disorders #oncology ... #diagnosis #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... and petechiae Causes ... • ↓ WBC • ↓ PLT ... #oncology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... - infiltrates (anemia ... and secondary lymphoid ... #Leukemia #Hematology ... #Oncology #Diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... hepatitis • Lymphoma ... • Nodules • Lymphoid ... autoimmune hemolytic anemia ... DDX - Other causes
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... Amyloidosis • Lymphoma ... Sarcoidosis) • Liver ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
common - GI tract, liver ... • No CRAB - no anemia ... UPEP, Serum IFE, FLC ... • Non-Hodgkin Lymphoma ... #Plasmacytoma #Oncology
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