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hematology differential monoclonal aplastic gammopathy gap management paraproteinemias protein proteingap significance undetermined
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
bone marrow + pancytopenia ... • ↓ WBC • ↓ PLT ... antithymocyte globulin ... #oncology #hematology ... #diagnosis #management
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... insufficiency, Anemia ... : • Abnormal FLC ... #Significance #hematology ... #diagnosis #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gammopathy Include: • MGUS ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... #differential #diagnosis ... #hematology
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