19 results
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Algorithm and Causes ... breakdown • Anaemia ... Hemolysis #Hemolytic #Anemia ... #Differential #Causes ... #Workup #Hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Increased ALP ... Intestine - Other causes ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC ... Diagnosis #Algorithm #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... for decreased PLT ... for decreased PLT ... changes), high MCV anemia ... #Workup #hematology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... ) Pathophysiology ... = nonspecific (nausea ... Cr, ↓Glucose, ↓PLT ... Liver #Pregnancy #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... intralobular bile ducts causes ... obstruction • ALP ... cholangitis #diagnosis #workup ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Pregnancy - AFLP ... Bile Ducts • PSC ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... • Pernicious anemia ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... diagnosis #algorithm #hepatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... • ↓ WBC • ↓ PLT ... #oncology #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... result in severe anemia ... immune hemolytic anemia ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology