12 results
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Pathophysiology ... obstruction • ALP ... cholangitis #diagnosis #workup ... #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... changes), high MCV anemia ... not required in all ... unclear, or if a primary ... #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
cases diagnosed during ... • Pernicious anemia ... collection with EDTA Pathophysiology ... • Elevation of urinary ... Hyophosphatasia #hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
mass • Rapidly rising ... - infiltrates (anemia ... count • ↓Hg & PLT ... + distinctive primary ... #Leukemia #Hematology
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
They work primarily ... upset (since it works ... That's because they work ... GLP1 #Agonists #Pharmacology ... #Dosing #Diabetes
Anemia of Hospitalization - Pathophysiology

Why does the Hgb/Hct drop in the first two days during hospitalization?

Interestingly,
- Pathophysiology ... adversely affecting all ... phlebotomy/ blood work ... lying down (Fox et al ... Hospitalization #causes #pathophysiology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
No evidence of anemia ... insufficiency, Anemia ... multiple myeloma, AL ... cells < 10% • Urinary ... #Significance #hematology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
Normal and Renal Dosing ... Increase Incretins (GLP-I ... DPP4 inhibitors work ... mechanism helps lower primarily ... #Pharmacology #
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... Transient K+ efflux moving ... Block K+ channels (primarily ... Antiarrhythmics #Pharmacology ... Classification #Classes #pathophysiology
Primary Biliary Cirrhosis - Management
A. Initiate therapy 
 - Initiate 1st line therapy with UDCA (13-15
Primary Biliary ... patients on UDCA using ... line therapy if ALP ... survey disease #PBC ... Management #Treatment #hepatology