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hematology diagnosis leukemia workup chronic cll lymphocytic management microscopy analysis aplastic bloodsmear borrelia causes cell differential disorders hemeonc interpretation myelodysplasia
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Smear Analysis ... Sickled red cells ... #hematology #microscopy ... interpretation #clinical
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Hypocellular/Hypoplastic MDS ... • ↓ WBC • ↓ PLT ... result from low blood ... #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Infection exposure (l MD ... plateletcount), peripheral blood ... smear, HIV/HCV ... changes), high MCV anemia ... dysplasia on the smear
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... syndromes with single-lineage ... smear • Bone marrow ... Syndromes #diagnosis #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
smear or on bone ... - infiltrates (anemia ... • Peripheral smear ... more aggressive form ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Peripheral smear ... immunophenotype Clinical ... 5) Symptoms of anemia ... Lauren Banaszak, MD ... Lymphocytic #Leukemia #oncology
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
Smear 23M Somali ... 12.5, WBC 14, Plt ... The table below ... be treated in a single ... microscopy #pathology #clinical
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Peripheral smear ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... diagnosis #workup #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
can present as a single ... plasmacytoma) Clinical ... • No CRAB - no anemia ... UPEP, Serum IFE, FLC ... #Plasmacytoma #Oncology
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