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hematology diagnosis oncology differential leukemia microscopy algorithm analysis aplastic bloodsmear borrelia causes cell chronic cll disorders interpretation lymphocytic management myelodysplasia
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Smear Analysis ... Sickled red cells ... #hematology #microscopy ... interpretation #clinical
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... plateletcount), peripheral blood ... smear, HIV/HCV ... changes), high MCV anemia ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Peripheral Smear ... for workup, including ... hematologic: Acute blood ... hemolysis, deficiency anemia ... Matthew Ho, MD
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Peripheral Smear ... syndromes with single-lineage ... Workup: • Complete ... smear • Bone marrow
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Hypocellular/Hypoplastic MDS ... • ↓ WBC • ↓ PLT ... result from low blood ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
smear or on bone ... - infiltrates (anemia ... • Peripheral smear ... more aggressive form ... #Leukemia #Hematology
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
Smear 23M Somali ... 12.5, WBC 14, Plt ... The table below ... be treated in a single ... microscopy #pathology #clinical
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Peripheral smear ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
can present as a single ... plasmacytoma) Clinical ... • No CRAB - no anemia ... Oncology #Diagnosis #Workup ... #Hematology
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