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diagnosis hematology oncology leukemia algorithm alkaline alp approach classification cll differential hyophosphatasia low lymphocytic management mds myelodysplasia myelodysplastic phosphatase syndromes
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
• Chronic Bleed ... Deficiency • Aplastic ... of Chronic Disease ... Diagnosis #Algorithm #Causes ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Anemia Clinical ... and petechiae Causes ... • ↓ WBC • ↓ PLT
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... -> AML: Blast crises ... - infiltrates (anemia ... • Peripheral smear ... more aggressive form
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... • Anemia • Aplastic ... Marrow Failure • Chronic ... Peripheral blood smear ... Syndromes #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Orange or Hep C Clinical ... • Peripheral smear ... • Neutropenia, anemia ... Pure red cell aplasia
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Adult form: Less ... thigh bones -> chronic ... • Pernicious anemia ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
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