6 results
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... leukemia • Solitary plasmacytoma ... syndrome) • Solitary plasmacytoma ... Connective tissue disorders ... Thalassemia, Sickle cell anemia
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... leukemia in adults • Disorder ... 5) Symptoms of anemia ... cytopenias (ITP, AIHA ... fludarabine) 3) Monoclonal
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Organomegaly+↑RBC/plt ... Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... lymphoproliferative disorders ... • Neutropenia, anemia ... thrombocytopenia • AIHA ... Leukemia #diagnosis #workup
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... activity • ↓ LAP ... - infiltrates (anemia ... /Cytopenias • AIHA ... #Leukemia #Hematology
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
Biopsy: Solitary disorder ... tissue composed of monoclonal ... • No CRAB - no anemia ... Oncology #Diagnosis #Workup ... #Hematology