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diagnosis hematology oncology cll lymphocytic management aplastic differential erythematosus gap globulin hemeonc lupus myelodysplasia protein proteingap rheumatology sle systemic
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Syndromes (MDS) ... formed or don’t work ... Marrow Failure • Chronic ... Myelogenous Leukemia ... Workup: • Complete
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... 5) Symptoms of anemia ... cytopenias (ITP, AIHA ... fludarabine) 3) Monoclonal ... Lauren Banaszak, MD
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... /Cytopenias • AIHA
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... • Sezary syndrome ... #CLL #Chronic ... #diagnosis #workup
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
• Hypocellular myelodysplastic ... syndrome (MDS) ... virus (EBV) • Leukemia ... • ↓ WBC • ↓ PLT ... #oncology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Plasma cell leukemia ... changes (POEMS syndrome ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Hematologic: • AIHA ... • Anemia of inflammation ... (C3 and C4) • ds-DNA ... with Lupus: • Chronic ... Hodgkin lymphoma and leukemia
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