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hematology oncology chronic cll differential lymphocytic cell globulin hemeonc management paraproteinemias plasmacytoma protein proteingap solitary
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... 5) Symptoms of anemia ... cytopenias (ITP, AIHA ... fludarabine) 3) Monoclonal ... #hemeonc #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... - infiltrates (anemia ... /Cytopenias • AIHA ... #Hematology #Oncology ... #Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt ... Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... Pseudohyponatremia • ↓anion gap ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Plasma cell leukemia ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia ... #differential #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... • Neutropenia, anemia ... thrombocytopenia • AIHA ... #diagnosis #workup ... #oncology #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... tissue composed of monoclonal ... • No CRAB - no anemia ... UPEP, Serum IFE, FLC ... #Workup #Hematology
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