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diagnosis hematology oncology chronic cll hemolytic lymphocytic agglutinin autoimmune causes cell cold disease disorders erythematosus gap globulin hemeonc lupus management
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... (AIHA) - Differential ... Diagnosis Table ... #AIHA #Differential ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... cytopenias (ITP, AIHA ... AIHA, PRCA) • Treatment ... fludarabine) 3) Monoclonal ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... thrombocytopenia • AIHA ... Hypogammaglobulinemia • Warm AIHA ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Significant ↓ PLT ... - infiltrates (anemia ... count • ↓Hg & PLT ... /Cytopenias • AIHA ... #Hematology #Oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt ... Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... • Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... changes), high MCV anemia ... Diagnosis #Causes #Workup ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Plasma cell leukemia ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Workup: • Complete ... blood count with differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Hematologic: • AIHA ... lymphopenia, low PLT ... • Anemia of inflammation ... Hodgkin lymphoma and leukemia
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