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diagnosis hematology cll differential lymphocytic cell globulin hemeonc management mds myelodysplasia myelodysplastic paraproteinemias plasmacytoma protein proteingap solitary syndromes
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... 5) Symptoms of anemia ... cytopenias (ITP, AIHA ... fludarabine) 3) Monoclonal ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... activity • ↓ LAP ... - infiltrates (anemia ... /Cytopenias • AIHA ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... #CLL #Chronic ... #diagnosis #workup ... #oncology #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt ... Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... Pseudohyponatremia • ↓anion gap ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Causes of Monoclonal ... • Plasma cell leukemia ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... Myelogenous Leukemia ... Workup: • Complete ... #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
tissue composed of monoclonal ... • No CRAB - no anemia ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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