9 results
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Diagnosis Algorithm ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... #injury #hepatitis ... diagnosis #algorithm
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Diagnosis Algorithm ... Cholestatic Pattern (ALP ... Ducts - PBC ... , PSC, Alcoholic ... Biliary stricture, PSC
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Diagnosis Algorithm ... ALP: - Enzymes ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC ... #Diagnosis #Algorithm
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... #Injury #Differential ... #Diagnosis #Causes
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Diagnosis Algorithm ... • Pregnancy - AFLP ... Bile Ducts • PSC ... #Diagnosis #Algorithm
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... Hepatitis, Preeclampsia ... iMedEducation #AFLP
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... obstruction • ALP ... or higher • Liver ... bile ducts Differential ... Viral hepatitis,
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... injury, though ... reported (eg AIH-PBC ... Anti-LKM & Anti-ALC ... (eg Viral) Management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Castleman disease • AL ... Sarcoidosis) • Liver ... , PBC, PSC, Viral ... Gap #ProteinGap #differential ... #diagnosis #hematology