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differential hematology aih algorithm autoimmune biliary cholangitis cirrhosis gap globulin hypogammaglobulinemia immunodeficiency immunology lfts liverenzymes pbc primary protein proteingap variable
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Female:Male 9:1 • Common ... intralobular bile ducts causes ... or higher • Liver ... : • Viral hepatitis ... #workup #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Bile Ducts • PSC ... • Alcoholic hepatitis ... Bile Ducts • Common ... #Algorithm #Causes
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... arthralgias) are common ... reported (eg AIH-PBC ... (eg Viral) Management ... #Management #Hepatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... diseases and hepatitis ... autoimmune hemolytic anemia ... DDX - Other causes ... #diagnosis #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Sarcoidosis) • Liver ... , PBC, PSC, Viral ... Thalassemia, Sickle cell anemia ... Comment on type ... #differential #diagnosis
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