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hepatology algorithm differential rheumatology alp biliary cholangitis cirrhosis elevation erythematosus hemophagocytic hepatitis hlh leukemia lfts liverenzymes lupus lymphohistiocytosis pbc phosphatase
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Intestine - Other causes ... - Drugs - Primary ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... intralobular bile ducts causes ... Labs: • Alkaline ... #workup #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
- Differential Diagnosis ... • Ischemia • Autoimmune ... • Drugs • AIH ... Bile Ducts • PSC ... #Algorithm #Causes
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... been reported (eg AIH-PBC ... , AIH diagnosis ... #Diagnosis #Management ... #Hepatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... assessment+++ Primary ... solid cancers • Autoimmune ... Drugs, Unknown cause ... #management #treatment
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... + distinctive primary ... /Cytopenias • AIHA ... #Leukemia #Hematology ... #Oncology #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... disease • Non-autoimmune ... the context of primary ... Antiribosomal P, APLA, PAC ... : • AIHA 10% •
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