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diagnosis algorithm differential primary causes cholangitis elevated gap globulin hematology hepatitis injury liver liverenzymes liverfunctiontests management protein proteingap transaminitis treatment
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Ducts - PBC ... , PSC, Alcoholic ... - CBD stone, Biliary ... stricture, PSC, ... Burak @kwburak #LFTs
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... • Fatigue PBC ... #Cirrhosis #PBC
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... function may be abnormal
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Bile Ducts • PSC ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... • Others #LFTs ... #Hepatology #LiverEnzymes
Primary Biliary Cirrhosis - Management A. Initiate therapy - Initiate 1st line therapy with UDCA (13-15
Primary Biliary ... Cirrhosis - Management ... 1.5x ULN and/or abnormal ... survey disease #PBC ... #Treatment #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Liver disease: Cirrhosis ... autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... chain assay • An abnormal
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