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diagnosis differential hematology cryofibrinogenemia cryoglobulins dermatologic dermatology erythematosus glomerulonephritis gpa granulomatosis lupus monoclonal oncology paraproteinemias polyangiitis progressive rapidly rash rpgn
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... • Vasculitis ... diagnosis #types #classification ... #rheumatology # ... vasculitis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Lupus Nephritis, Cryoglobulinemia ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... ANCA +MPO) • Cryoglobulinemic ... Low levels mixed cryoglobulinemia ... differential #diagnosis #rheumatology ... #classification
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... purpura (16%) • Painful ... purpura • Mixed cryoglobulinemia ... Granulomatous vasculitis ... rash #diagnosis #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... , sepsis or cryoglobulinemia ... sensitivity • Painful ... reticularis • Painful ... Calciphylaxis • Cryoglobulinemia
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Immunotactoid GN & Cryoglobulinemic ... Organomegaly+↑RBC/plt ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic ... Paraproteinemias #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... lymphopenia, low PLT ... Erythematosus #Diagnosis #Rheumatology
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