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Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Primary: 50% Cutaneous ... Urticarial/LCV) - Cryoglobulinemic ... : • Cutaneous ... : • Behcet Disease ... #dermatology #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... Henoch-Schönlein purpura) • Cutaneous ... diagnosis #types #classification ... #rheumatology # ... vasculitis
Behcet's Syndrome - Diagnosis
Diagnostic Criteria for Behget's Syndrome (International Study Group for Behget's Disease):
 • Recurrent,
Behcet's Syndrome ... Uveitis or retinal vasculitis ... Clinical Features: • Painful ... uveitis, retinal vasculitis ... Diagnosis #criteria #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... Vasculitis Vasculitis ... syndrome - Behcet ... dermatomyositis #Size #Classification ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
: • Behçet Syndrome ... aphthous ulcers, cutaneous ... strong sign of cutaneous ... differential #diagnosis #rheumatology ... #classification
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... aphthous ulcerations (painful ... ) • Cutaneous Lesions ... azathioprine #Behcet ... signs #symptoms #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Strong sign of cutaneous ... / ANCA + MPO) Cryoglobulinemic ... (lower legs), cutaneous ... • Behcet syndrome ... Differential #Diagnosis #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
gangrenosum • Cutaneous ... Immunotactoid GN & Cryoglobulinemic ... Organomegaly+↑RBC/plt ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... purpura (16%) • Painful ... purpura • Mixed cryoglobulinemia ... Granulomatous vasculitis ... rash #diagnosis #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... , sepsis or cryoglobulinemia ... sensitivity • Painful ... reticularis • Painful ... Calciphylaxis • Cryoglobulinemia