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diagnosis differential syndrome cryoglobulins dermatology disease erythematosus hematology lupus monoclonal oncology paraproteinemias signs sjogrens skin sle symptoms systemic types vasculitides
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Primary: 50% Cutaneous ... Urticarial/LCV) - Cryoglobulinemic ... : • Cutaneous ... : • Behcet Disease ... #dermatology #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... Henoch-Schönlein purpura) • Cutaneous ... diagnosis #types #classification ... #rheumatology # ... vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Behçet Syndrome ... aphthous ulcers, cutaneous ... strong sign of cutaneous ... differential #diagnosis #rheumatology ... #classification
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... aphthous ulcerations (painful ... ) • Cutaneous Lesions ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Strong sign of cutaneous ... / ANCA + MPO) Cryoglobulinemic ... (lower legs), cutaneous ... • Behcet syndrome ... Differential #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... Immunotactoid GN & Cryoglobulinemic ... Organomegaly+↑RBC/plt ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... : • Acute cutaneous ... Non-autoimmune rheumatologic ... lymphopenia, low PLT ... Erythematosus #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
skin (xerosis) • Cutaneous ... vasculitis: 10% ... : • 7%, Cryoglobulinemia ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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