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Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Vasculitis Involving ... Urticarial/LCV) - Cryoglobulinemic ... - Microscopic polyangiitis ... : • Behcet Disease ... #dermatology #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... - microscopic polyangiitis ... syndrome - Behcet ... dermatomyositis #Size #Classification ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... EGPA, microscopic polyangiitis ... diagnosis #types #classification ... #rheumatology # ... vasculitis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Granulomatosis with Polyangiitis ... granulomatosis with polyangiitis ... purpura (16%) • Painful ... purpura • Mixed cryoglobulinemia ... rash #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
• Microscopic Polyangiitis ... ANCA +MPO) • Cryoglobulinemic ... : • Behçet Syndrome ... differential #diagnosis #rheumatology ... #classification
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
: Microscopic polyangiitis ... Granulomatosis with Polyangiitis ... / ANCA + MPO) Cryoglobulinemic ... • Behcet syndrome ... Differential #Diagnosis #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Immunotactoid GN & Cryoglobulinemic ... Organomegaly+↑RBC/plt ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic ... Differential #Diagnosis #Oncology