16 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... common sites: hip, shoulder ... Osteomyelitis / Septic Arthritis ... • Differentiate ... #hematology
Gout (Gouty Arthritis) - MSK Radiology
Imaging Findings:
 • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
) - MSK Radiology ... • This case should ... Differential diagnosis ... • PVNS/Giant Cell ... #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... axial (spine, shoulders ... constitutional symptoms ... Joint #pain #Differential ... #Diagnosis #MSK
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... symptoms (headache ... Behcet disease) Differential ... Nonsurgical abdominal pain ... #rheumatology #
13 Dangerous Causes of Headache:
 - subarachnoid hemorrhage: family history, PCKD, known berry aneurysm, sudden and
13 Dangerous Causes ... temporal (giant cell) arteritis ... claudication, shoulder ... dissection: unilateral pain ... Dangerous #Deadly #Differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... burning sensation or pain ... • Giant cell arteritis ... Polyangiitis #GPA #dermatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... disease (younger pts ... ) Differential ... chills, flank pain ... hemolytic #anemia #hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... Clinical Features ... nonerosive inflammatory arthritis ... Rule out other causes ... diagnosis #management #Dermatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Presentation: Systemic Symptoms ... proximal muscles of shoulder ... • Progressive symptoms ... tract, and often causes
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... healthy adults, and should ... context of other symptoms ... likely it will be clinically ... #diagnosis #differential