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diagnosis management rheumatology anemia activation agglutinin antinxp2 antinxp2dm bronchiectasis classification cold common cvid dermatomyositis disease extravascular hemolysis hodgkins hypogammaglobulinemia immunodeficiency
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... uremic syndrome ... hemoglobinuria (PNH ... #differential # ... diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... deficiencies - PNH ... #Diagnosis #hematology ... #nonpalpable #dermatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... disease (younger pts ... ) Differential ... #anemia #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... nervous system (CNS ... rash) • Heart, lung ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... • Chronic lung ... and autoimmune hemolytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
• Mounier-Kuhn syndrome ... in the adjacent lung ... of the affected lung ... mycobacteria Treatment ... Bronchiectasis #pulmonary #differential
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... Rheumatic pain Clinical ... Rule out other causes ... and lower jaw Treatment ... diagnosis #management #Dermatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... MALT Lymphoma • Lung ... Adenocarcinoma Treatment
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... nodosum • Immune hemolytic ... Immunohistochemical studies (to differentiate ... Hodgkin Lymphoma Treatment ... classification #hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
subcutaneous edema Pts ... auricular papules Clinical ... Muscle atrophy may cause ... positive patients Treatment ... #dermatology
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