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diagnosis rheumatology msk arthritis vasculitis alkaline alp approach autoimmune bone classification disease effusions extremity hepatology hyophosphatasia knee leg low lower
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Early dz difficult ... • Differentiate ... #diagnosis #causes ... #hematology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... Like in this case ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Leg Pain - Differential ... Causes of Leg Pain ... ulcers, Edema Arterial ... Causes of Leg Pain ... extremity #msk #physicalexam
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Approach to Joint ... Differential Diagnosis ... weeks) Can Be Caused ... #pain #Differential ... Diagnosis #MSK #rheumatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
prematurely • risk of joint ... membrane into the CNS ... (muscle/joint) ... Waddling gait - Difficulty ... Phosphatase: • Other causes
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Causes of Knee Effusions ... - Differential ... Fever/Chills/Joint ... pain/Night sweats ... diagnosis #msk #physicalexam
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
vesicular eruption • Joints ... tract, and often causes ... Palpable purpura, joint ... involvement, abdominal pain ... Thrombosis and arterial
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... tract, and often causes ... vesicular eruption - Joints ... syndrome - Coronary arteries ... Thrombosis and arterial
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Syndrome: Fever, joint ... aspiration > 50% of pts ... statins - probably caused ... #differential #
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