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differential rheumatology anemia dermatology agglutinin autoimmune clinical cold disease extravascular hemolysis intravascular management myopathy myositis nikolskys nonpalpable palpable purpura sign
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... uremic syndrome ... hemoglobinuria (PNH ... #hematology #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... reticularis • Raynaud ... Diagnosis: • hemolytic ... disease (younger pts ... #anemia #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... DIC/TTP/HUS - Hemolytic ... Kasabach-Merritt syndrome ... deficiencies - PNH ... Gardner-Diamond syndrome
Nikolsky's Sign in Toxic Epidermal Necrolysis (TEN) Nikolsky's sign is a clinical dermatological sign which is present
Stevens-Johnson Syndrome ... , caused by the ... differentiating between the diagnosis ... #PhysicalExam # ... Video #Clinical
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 Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Cryoglobulinemia (4%-12%), Raynaud ... Diagnosis #Management
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... joint pain and Raynaud ... aspiration > 50% of pts ... • Myositis • Raynaud ... statins - probably caused
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