7 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... autoantibodies that will cause ... #CNS #neurology ... #management #treatment
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
CNS Ring-Enhancing ... + MRI lesions + ... toxo IgG • CNS ... 30% present w/ CNS ... @AnnKumfer #CNS
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... : CNS manifestations ... , hypoxia, CXR - ... • Tumor lysis syndrome ... #Leukemia #Hematology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... • Infectious causes ... brain and/or optic ... Disorders: - SLE ... Myelitis #diagnosis #management
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... Diagnosis #Management
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... involve anterior chest ... Rule out other causes ... - MRI: inflammation ... diagnosis #management
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
diseases, such as SLE ... oligoclonal bands • MRI ... tract, and often causes ... chorioretinitis, CNS ... vasculitis • Cogan syndrome