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diagnosis differential treatment intravascular oncology syndrome algorithm blood extravascular hemolysis product reactions anemia antinxp2 antinxp2dm arterial arthritis classification clinical clots
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... neoplasms - PNH ... MAHA: TTP, HUS, DIC ... Diagnosis #clots #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
marrow disease - DIC ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • PCH • PNH ... • MAHA (TTP, DIC ... Diagnosis #Algorithm #Causes ... #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thromboembolism (7%) • CNS ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation (DIC ... hemoglobinuria (PNH ... Extravascular #Causes ... differential #diagnosis #hematology
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
#management #algorithm ... #decisionaid #cardiology ... #hematology #warfarin
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... children, so I did ... Cr>2.3 & platelets ... Microangiopathy #TMAs #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... • Nephrogenic DI ... Hematologic: ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... manifestations, hypoxia, CXR ... Fibrinolysis & DIC ... #Leukemia #Hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... , dyspnea, +/- CXR ... acid, Elevated Cr ... TLS #diagnosis #management ... #hematology
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