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diagnosis differential management rheumatology common cvid essential et fatigue hypogammaglobulinemia immunodeficiency immunology myopathy myositis polycythemia sjogrens syndrome thrombocythemia variable workup
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... Hepatitis • HIV Autoimmune ... Myasthenia Gravis Pharmacologic ... #causes
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
increased infection risk ... noninfectious complications ... Autoimmunity • Chronic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... effusion, INC risk ... Nephrogenic DI Hematologic ... Malignancy Risk ... lubricants • Pharmacologic
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... an underlying cause ... circulation = risk ... Better call hematology ... normal/high - Chronic
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
(ET) ET is a chronic ... Most cases are related ... , symptoms and complications ... • Treatment algorithms ... patients with no CV risk
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
aspiration > 50% of pts ... statins - probably caused ... ANTI-MITOCHONDRIAL MYOPATHY: • Chronic ... muscular atrophy • Chronic ... Myositis #Myopathy #rheumatology
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