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diagnosis management oncology sle erythematosus differential mds myelodysplastic activation algorithm autoimmune cerebritis chronic classification cll cns comparison cryoglobulinemia cryoglobulins dermatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
of Systemic Lupus ... Demyelinating Syndrome ... Aseptic Meningitis, Myelopathy ... autoantibodies that will cause ... #rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management Summary ... • Immunologic Workup ... life-threatening • Treatment ... #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... severe disease Treatment ... #SLE #Summary # ... diagnosis #rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Muscle Toxicity - Summary ... (GBS), systemic ... lupus erythematosus ... (LEMS), systemic ... Pitavastatin Risk
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... and Management Summary ... old, ~10,000 new cases ... • Risks: infection ... #hematology #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... (CNS) dysfunction ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
neuropathy) • Systemic ... late-onset nemaline myopathy ... Amyloidosis (CVS+PNS ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months to years) Systemic ... • Immunologic Workup ... life-threatening • Treatment ... comparison #table #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... • May involve PNS ... Thrombosis highest risk ... #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
effusion, INC risk ... Nephrogenic DI Hematologic ... Malignancy Risk ... Adenocarcinoma Treatment ... #Rheumatology #
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