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diagnosis betadglucan differential galactomannan latenttb tb treatment tuberculosis aspergillus biomarkers cd4 chest clinical comparison ct cxr evaluation falsepositives hivaids infections
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
Pulmonary Infections ... > 200: Endemic fungi ... , Endemic fungi ... failure, COPD, Lung ... • CD4 < 200: Pulmonary
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
component of many fungi ... infection (IFI) ... admin of mold-active ... closely related fungi ... setting of GVHD) ID
Miliary Pattern - Chest Radiology • Miliary opacities are scattered, small (1 -4 mm) nodules •
throughout the lungs ... Opacities: • Infectious ... - Endemic fungi ... , Sarcoidosis, HSP ... differential #diagnosis #pulmonary
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
affecting the lungs ... (NTM) • Fungal ... • Lymphoma • Lung ... • Progressive lung ... TB #Diagnosis #Management
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
affecting the lungs ... (NTM) • Fungal ... • Lymphoma • Lung ... • Progressive lung ... TB #Diagnosis #Management
Nocardiosis - Nocardia spp Pathogen: Filamentous gram-positive branching rod, grows in acid fast staining and anaerobic conditions Clinical
involved) 32% • Pulmonary ... Primary site of infection ... 9%, up to 20% lung ... Nocardia #diagnosis #management ... #microbiology #
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
component of many fungi ... surfaces, Albumin, Infections ... concurrent admin mold-active ... result in + as long ... closely related fungi
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