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diagnosis differential infections brain causes infectiousdiseases betadglucan galactomannan aspergillus biomarkers cd4 chest clinical comparison ct cxr evaluation falsepositives hivaids laboratory
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
Pulmonary Infections ... > 200: Endemic fungi ... , Endemic fungi ... failure, COPD, Lung ... • CD4 < 200: Pulmonary
Differential Diagnosis for Concurrent Brain and Lung Infections • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
Diagnosis for Concurrent ... Brain and Lung ... Toxoplasmosis • Fungi ... ID_fellows #Brain #Lung ... #Infections #Concurrent
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
component of many fungi ... infection (IFI) ... decreased with: concurrent ... closely related fungi ... setting of GVHD) ID
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... febrilepodcast #Brain #Lung ... #Infections #Concurrent
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... febrilepodcast #Brain #Lung ... #Infections #Concurrent
Miliary Pattern - Chest Radiology • Miliary opacities are scattered, small (1 -4 mm) nodules •
throughout the lungs ... Opacities: • Infectious ... - Endemic fungi ... , Sarcoidosis, HSP ... differential #diagnosis #pulmonary
Nocardiosis - Nocardia spp Pathogen: Filamentous gram-positive branching rod, grows in acid fast staining and anaerobic conditions Clinical
involved) 32% • Pulmonary ... Primary site of infection ... 9%, up to 20% lung ... Nocardia #diagnosis #management ... #microbiology #
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
component of many fungi ... surfaces, Albumin, Infections ... Sensitivity ↓ w/concurrent ... result in + as long ... closely related fungi
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