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differential hematology agglutinin aids algorithm anemia cold globulin hepatitis hepatology infections infectiousdiseases injury liver management monoclonal neurology oncology opportunistic paraproteinemias
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome (CAS ... Diagnosis: • hemolytic ... - Mycoplasma, EBV ... , HIV, rubella legionella ... sensitize red blood cells
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... EBV, HSV, CMV, ... Bilirubin: RBC (hemolysis ... intestines, white blood cells ... #differential #diagnosis
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Diagnosis Framework ... per μL • Diagnosis ... Demyelinating disease ... effect/Edema • EBV ... #differential #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Zone Lymphoma (HCV ... Scleromyxedema (Dermato-neuro ... • Coombs (-) hemolytic ... Pseudohyponatremia • ↓anion gap ... #Differential #Diagnosis
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... ulcers, nodules • Neuro ... mononeuritis multiplex WORKUP ... antibody, Anti-GBM
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Heavy chain disease ... infections (acute HIV ... , HBV, EBV, VZV, ... #differential #diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Multinucleated giant cells ... MPO > PR3 60/ GPA ... pain and GN Anti-GBM ... chorioretinitis, CNS
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