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diagnosis hematology autoimmune causes cold disease disorders erythematosus gap globulin hemolytic lupus myopathy myositis platelet protein proteingap sle systemic thrombocytopenia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... - Mycoplasma, EBV ... younger pts) Differential ... Hemoglobinuria (PCH ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... procedures - Infection ... . pylori test (GI ... changes), high MCV anemia ... When do you do a BM
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • Viral infections ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... fibromyalgia) • Infections ... pericardial/abd GI ... Antiribosomal P, APLA, PAC ... lymphopenia, low PLT • Anemia
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Tenderness → Consider infectious ... • ANA < 20 % IBM ... Other Diseases: • PBC ... #differential #
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