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diagnosis hematology hodgkins lymphoma agglutinin autoimmune causes classification cold comparison disease disorders erythematosus gap globulin hemolytic lupus management myopathy myositis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... - Mycoplasma, EBV ... younger pts) Differential ... Hemoglobinuria (PCH ... #hematology #diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... infection, Autoimmune ... Extranodal disease: GI ... NonHodgkins #comparison #oncology ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... procedures - Infection ... . pylori test (GI ... changes), high MCV anemia ... When do you do a BM
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • Viral infections ... acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... infection • Family ... Weight loss • Anemia ... Immunohistochemical studies (to differentiate ... #oncology #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... fibromyalgia) • Infections ... pericardial/abd GI ... Antiribosomal P, APLA, PAC ... lymphopenia, low PLT • Anemia
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Tenderness → Consider infectious ... • ANA < 20 % IBM ... Other Diseases: • PBC ... #differential #
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