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diagnosis hepatology algorithm injury causes rheumatology transaminitis acute antibodies associations autoantibodies autoimmune cns diseases gap globulin hepatocellular hiv infections infectiousdiseases
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Hepatocellular - Liver ... C, A, E, B, D, EBV ... Artery: Shock Liver ... Sophia_Hayes_MD #Liver
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... normal - Infection (EBV ... #Patterns #Liver ... #LFTs #transaminitis ... #differential #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... HBV, HCV, HEV, EBV ... , PBC, PSC, IgG4 ... #differential # ... diagnosis #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... Hepatocellular Liver ... A/B/C/D/E, EBV, ... Transaminitis #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Bile Ducts • PSC ... • Alcoholic hepatitis ... • Others #LFTs
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
SLE, autoimmune hepatitis ... Dermatomyositis Anti-LKM (liver ... ) - Autoimmune hepatitis ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Infection in HIV / AIDS ... - Differential ... lesions < 4cm + mass ... effect/Edema • EBV ... #diagnosis #AIDS
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... , PBC, PSC, Viral ... Gap #ProteinGap #differential ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... • ANA < 20 % IBM ... Other Diseases: • PBC ... , autoimmune hepatitis ... #differential #
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