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hematology agglutinin behcet causes classification cold erythematosus hemolysis hemophagocytic hlh hodgkins intravascular lupus lymphohistiocytosis macrophage mas oncology signs sle summary
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... e.g. lupus, CLL, lymphoma ... #Causes #differential ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... Diagnosis: • hemolytic ... anemia • Cold ... #hemolytic #anemia ... #hematology #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... • Clinical: fever ... , B-cell lymphoma ... #management #treatment ... #summary #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... - Clinical Presentation ... anemia • Pain ... Treatment • Early ... #management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
matter, spinal cord ... ) Differential Diagnosis ... Arthritis, AS Treatment ... Nonsurgical abdominal pain ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
SLE], AOSD) • Infection ... with leukopenia, anemia ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Management #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... fibromyalgia) • Infections ... Arthritis: • Joint pain ... lymphopenia, low PLT • Anemia ... Chronic B-cell activation
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