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diagnosis differential hematology management treatment common cvid disease gap hypogammaglobulinemia igg4 immunodeficiency immunology phenotypes polycythemia proteingap prs pulmonary related renal
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... biliary, renal, lung ... concentration PET-CT ... management #phenotypes #workup ... #treatment #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Heavy chain disease ... plasmacytoma • Castleman disease ... Sarcoidosis) • Liver disease ... ovarian tumors, lung
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung ... lymphocytic interstitial lung ... Chest CT: • Ground-glass ... DDX - Other causes ... syndrome • Burns • Protein-losing
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
mononeuritis multiplex WORKUP ... Urine: UA, Urine protein ... Other tests: • CT ... Goodpasture's cause ... sparing of the lung
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... , this list is long ... about secondary causes ... As with many disease ... #workup #hematology
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