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management workup differential common cvid disease erythematosus evaluation hematology hivaids hypogammaglobulinemia igg4 immunodeficiency immunology infections lupus myopathy myositis phenotypes pulmonary
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
failure, COPD, Lung ... Evaluation: Imaging (CXR ... +/- High res CT ... Infectious Diseases ... HIVAIDS #workup #diagnosis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... (interstitial lung ... disease), PAH ( ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... female, asian • Systemic ... biliary, renal, lung ... concentration PET-CT ... workup #treatment #rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung ... lymphocytic interstitial lung ... Chest CT: • Ground-glass ... : Pneumonia • Autoimmune ... hemolytic anemia) • Systemic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... /aggregate) of CD4 ... Central nervous system ... MALT Lymphoma • Lung ... Sjogrens #Syndrome #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... , pancreas, stomach ... , pancreas, stomach ... • Conduction system ... : • PBC, autoimmune
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